![]() Helps PIs to develop protocols and procedures for collecting and storing samples.Teaches and trains undergraduate and graduate students and junior investigators in laboratory techniques.Works in tandem with the ACTRI Biomedical Informatics Division to provide secure data storage and retrieval.Helps physicians to develop and validate disease- and patient-oriented biomarker assays.Introduces and validates (GLP) new assays, as pilot studies, with commercial QC and internal quality assurance program (IQAP) support.Performs all validated assays with internal and commercial QC in a timely manner.Assays are provided at affordable cost to investigators carrying out clinical, translational, and basic research at UC San Diego and at our Partner Institutions. The Biomarker Laboratory provides analyte determinations on a variety of human and animal materials principally through immunoassays and quantitative PCR. ![]() The three principal uses of biomarkers are as (1) surrogate markers of disease (2) proof-of-concept indicators, in that they aid in development decisions (“Go/No Go” to the next study) and (3) a means to understanding the mechanisms of action of drugs. We measure biomarkers as either expression at the mRNA and protein level or as functional activity. For example, in inflammatory diseases, typical biomarkers include cytokines (e.g., IL-1, TNF-alpha), metalloproteinases and small molecule mediators (e.g., prostaglandins). Please click on the “ Request ACTRI Services” button for information on contacting the laboratories described below.īiomarkers are biological indicators that signal a changed physiological state due to disease or a therapeutic intervention. Through the TRT Laboratories, investigators will have access to the Biomarker Laboratory.
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